The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery
This trial is active, not recruiting.
|Treatment||red blood cell transfusion|
|Sponsor||Hvidovre University Hospital|
|Start date||January 2004|
|End date||March 2006|
|Trial size||120 participants|
|Trial identifier||NCT00162617, HHSG-RCT-03|
To examine the effect of two different transfusion regimens on rehabilitation after hip fracture surgery.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
Postoperative Functional mobility
Restricting factors for functional mobility
Length of stay
Haematoma (leg swelling)
Male or female participants at least 65 years old.
- Primary hip fracture
- capable of informed consent
- independently dwelling
- able to ambulate independent of human assistance
- no active heart condition defined as no AMI within 3 months, no unstable angina or present incompensation/pulmonary oedema
- no regular transfusion demand or terminal disease.
- Multiple fractures
- postop. immobilization due to to surgical reasons
- patient refusal to participate in relevant rehabilitation
- reoperation within 4. postoperative day.
|Official title||The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery|
|Description||The effect of liberal vs restrictive transfusion regimens after hip fracture surgery is unresolved. Liberal transfusion regimens (transfusion trigger hgb. 6.25 mmol/l) leads to an increased use of blood products but may impact positively on rehabilitation outcome, a restrictive transfusion trigger (hbg. 5.0 mmol/l) saves blood products but may also impair postoperative rehabilitation and outcome. the study randomizes 120 elderly patients with hip fractures to either a restrictive or a liberal perioperative transfusion therapy and measures postoperative rehabilitation outcomes within a well defined multimodal rehabilitation regimen.|
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