Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
This trial is active, not recruiting.
|Condition||induction of total intravenous general anesthesia|
|Treatments||kétamine 20mg, ephedrine 3mg, lidocaine 40mg|
|Sponsor||Hospices Civils de Lyon|
|Start date||September 2005|
|Trial size||200 participants|
|Trial identifier||NCT00146926, 2004.367|
Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.
|Intervention model||parallel assignment|
After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness
Explicite and implicite memory of pain immediately after surgery and on day one
Male or female participants from 18 years up to 75 years old.
Inclusion Criteria: Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol Exclusion Criteria: - pregnant - sedative or analgesic drug 24h before surgery - allergy with drug used in the study - difficulty of communication - absence of informed written consent
|Official title||Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion|
|Principal investigator||Vincent PIRIOU, MD|
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