This trial is active, not recruiting.

Condition follicular lymphoma
Treatments rituximab
Phase phase 3
Target CD20
Sponsor Lymphoma Study Association
Collaborator HOVON - Dutch Haemato-Oncology Association
Start date December 2004
End date May 2007
Trial size 1217 participants
Trial identifier NCT00140582, PRIMA


- Objectives

- Primary objective: To evaluate in patients with advanced follicular lymphoma the benefit of maintenance therapy with rituximab after induction of response with chemotherapy plus rituximab in comparison with no maintenance therapy

- Secondary objective: To evaluate response rates, event driven survival endpoints (EFS, PFS, OS) and quality of life of four different chemotherapy regimens combined with rituximab, with or without maintenance with rituximab, for first line treatment of advanced stage follicular lymphoma.

- Study Design This is an international open-label, multicentre, randomized study with two treatment phases. In the induction phase patients have to respond to 1st line induction treatment in order to be eligible for randomization to the second phase of maintenance treatment or observation. After the maintenance period patients will be included in the follow up phase for 3 years.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
One infusion of rituximab (375 mg/m2) every 2 months for 2 years (12 infusions)
one infusion of rituximab (375 mg/m2) every 2 months for 2 years
maintenance with rituximab for 2 years
(No Intervention)
no further treatment

Primary Outcomes

Progression Free Survival (PFS)
time frame: number of event observed driven : 344 events or 10 years

Secondary Outcomes

Response rates, event driven survival endpoints (EFS, PFS, OS)
time frame: number of event observed driven : 344 events or 10 years
Quality of life
time frame: number of event observed driven : 344 events or 10 years

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Histologically confirmed follicular lymphoma grade 1, 2 or 3a. - Patients previously untreated. - Patients with at least one of the following symptoms requiring initiation of treatment: - Bulky disease at study entry according to the GELF criteria: nodal or extranodal mass > 7cm in its greater diameter - B symptoms - Elevated serum LDH or beta2-microglobulin - involvement of at least 3 nodal sites (each with a diameter greater than 3 cm) - symptomatic splenic enlargement - compressive syndrome - pleural/peritoneal effusion - Age must be > 18 years. - Performance status < 2 on the ECOG scale (see appendix E). - Adequate hematological function within 28 days prior to registration (unless those abnormalities are related to lymphoma extension), this includes: - Hemoglobin ≥ 8.0 g/dl (5.0 mmol/L) - Absolute neutrophil count (ANC) ≥ 1.5 109/L - Platelet count ≥ 100 109/L - Women are not breast feeding, are using effective contraception, are not pregnant and agree not to become pregnant during participation in the trial and during the 12 months thereafter. Men agree not to father a child during participation in the trial and during the 12 months thereafter. - Having previously signed a written informed consent form. Exclusion Criteria: - Transformation to high-grade lymphoma (secondary to "low-grade" follicular lymphoma). - Grade 3b follicular lymphoma. - Presence or history of CNS disease (either CNS lymphoma or lymphomatous meningitis). - Patients regularly taking corticosteroids during the last 4 weeks, unless administered at a dose equivalent to < 20 mg/day prednisone. - Patients with prior or concomitant malignancies except non-melanoma skin cancer or adequately treated in situ cervical cancer. - Major surgery (excluding lymph node biopsy) within 28 days prior to registration. - Poor renal function: Serum creatinine > 2.0 mg/dl (197 μmol/L), - Poor hepatic function: total bilirubin > 2.0 mg/dl (34 μmol/L), AST (SGOT) > 3 x the upper limit of normal unless these abnormalities are related to lymphoma. - Known HIV infection or active HBV or HCV infection. - Serious underlying medical conditions, which could impair the ability of the patient to participate in the trial (e.g. ongoing infection, uncontrolled diabetes mellitus, gastric ulcers, active autoimmune disease). Judgment is up to the investigator. - Life expectancy < 6 months - Known sensitivity or allergy to murine products - Treatment within a clinical trial within 30 days prior to trial entry - Adult patient under tutelage.

Additional Information

Official title Advanced Follicular Lymphoma Evaluating the Benefit of Maintenance Therapy With Rituximab (MabThera®) After Induction of Response With Chemotherapy Plus Rituximab in Comparison With no Maintenance Therapy
Principal investigator Gilles A Salles, MD PhD
Description Study medication - First period: Induction of response with 8 x rituximab combined with 8 cycles of CVP or 6 cycles of CHOP in 21-day cycles or 6 cycles of FCM in 28-day cycles or 6 cycles of MCP in 28-day cycles. - Second period: rituximab 375 mg/m2 every 8 weeks for 24 months (12 injections) or control with no treatment
Trial information was received from ClinicalTrials.gov and was last updated in September 2015.
Information provided to ClinicalTrials.gov by Lymphoma Study Association.