This trial is active, not recruiting.

Condition tonsillitis
Treatment (adeno)tonsillectomy
Sponsor Oulu University Hospital
Start date October 2001
End date December 2005
Trial size 70 participants
Trial identifier NCT00136877, Diary nro 135/2001


The purpose of this study is to determine whether tonsillectomy is effective in preventing further streptococcal pharyngitis episodes in patients with recurrent tonsillitis.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification safety/efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment

Primary Outcomes

microbiologically confirmed streptococcal pharyngitis episodes
time frame:

Secondary Outcomes

side effects
time frame:
time frame:
quality of life issues
time frame:

Eligibility Criteria

Male or female participants at least 14 years old.

Inclusion Criteria: - At least 3 tonsillitis episodes during the preceding year (at least one verified by culture or antigen testing) Exclusion Criteria: - Other serious illness - Long term antibiotic treatment for other disease - Documented immunologic disorder - Pregnancy

Additional Information

Official title Effect of Tonsillectomy on Preventing Recurrent Streptococcal Throat Infections: A Randomized Controlled Trial
Description Tonsillectomy is widely used worldwide in recurrent streptococcal tonsillitis, but its effect remains unknown. In this randomized controlled trial, the effect of tonsillectomy (compared to watchful waiting) in preventing further culture proven symptomatic streptococcal pharyngitis episodes is studied. In addition, symptoms after the operation, side effects, and life quality issues are recorded.
Trial information was received from ClinicalTrials.gov and was last updated in December 2006.
Information provided to ClinicalTrials.gov by Oulu University Hospital.