This trial is active, not recruiting.

Condition borderline personality disorder
Treatments cognitive therapy, supportive therapy
Sponsor Hospices Civils de Lyon
Start date March 2001
Trial size 70 participants
Trial identifier NCT00131781, 2000.230


This is a randomised trial comparing cognitive therapy and supportive therapy administered along one year in borderline personality disorder. The follow-up is one year after treatments end.

The therapists were the same in the two groups. Patients received one session a week during six months and one session every two weeks during the next six months

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Intervention model parallel assignment
Masking single blind

Primary Outcomes

Clinical Global Impression (CGI): Improvement (1-7): score 3 ( a little better) associated with a hopelessness scale score < 8 (this means that the suicide risk is low)
time frame:

Secondary Outcomes

CGI severity and improvement
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Hamilton depression
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Beck Depression Inventory
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Young: Schema Questionnaire II
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Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Personality Disorders Personality Questionnaire (SCID II PQ)
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Minnesota Multiphasic Personality Inventory (MMPI) (minimult)
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Eysenck: impulsivity scale
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Checklist: impulsive risky behaviors
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Quality of life
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Handicap (Sheehan)
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Time: Pre test, six months, post test and one year post treatment follow-up
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Therapeutic relationship evaluation scale (patients and therapists)
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Eligibility Criteria

Male or female participants from 18 years up to 65 years old.

Inclusion Criteria: - DSM-4 DIBR >=8 (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Diagnostic inventory for borderline-revised)

Additional Information

Official title Cognitive Therapy Versus Supportive Therapy in Borderline Personality Disorder
Principal investigator Jean COTTRAUX, MD
Description - Cognitive Therapy - Structured session - Conceptualization of the case with the patient - Cognitive methods - Guided discovery of the schemas - Work on life-scenarios - From scenarios to schemas - Empathic confrontation to the schemas - Building new schemas (Core belief work-sheet) - Affective methods: role playing - Interpersonal methods: counter transference issues - Behavioral experiment - Problem solving - Consolidation methods - Patients and therapists had manuals - Supportive Therapy - Therapist: active listening (face to face) - Empathy - Unconditional positive regard - Reformulation and clarification - Reflection of the patient’s feelings - Reassurance - Therapist emphasizes the importance to ventilate problems - Therapist answers some factual questions - Therapist politely ignore or refuse requests for advice and directive attitudes - Therapist demonstrates warmth and genuineness - Patients and therapists had manuals
Trial information was received from ClinicalTrials.gov and was last updated in April 2007.
Information provided to ClinicalTrials.gov by Hospices Civils de Lyon.