CARMEDAS: Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis
This trial is active, not recruiting.
|Treatment||contrast-enhanced magnetic resonance angiography|
|Sponsor||Hospices Civils de Lyon|
|Start date||April 2001|
|Trial size||300 participants|
|Trial identifier||NCT00131001, 99.203|
PURPOSE: The purpose of this clinical trial is to study the cost-effectiveness ratios of diagnostic strategies for the imaging assessment of symptomatic carotid stenosis.
MATERIALS AND METHODS: The diagnostic accuracies of Doppler ultrasound (DUS), contrast-enhanced magnetic resonance angiography (CEMRA) and computed tomography angiography (CTA) were compared with digital subtraction angiography (DSA) in a multicenter study (CARMEDAS; 206 patients assessable) and in a meta-analysis (for CEMRA and CTA). The direct costs of each imaging method were calculated in 2 university medical centers. Eight hypothetical models were studied with DUS considered as the first-line imaging method and either CEMRA or CTA or DSA as the second or third line method. The effectiveness criterion was the number of potential avoided strokes for each strategy and for 1000 patients.
|Intervention model||single group assignment|
To study the cost-effectiveness ratios of diagnostic strategies for the imaging assessment of symptomatic carotid stenosis
Male or female participants from 18 years up to 90 years old.
Inclusion Criteria: Carotid artery stenosis > 50%
|Official title||Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis|
|Principal investigator||Philippe DOUEK, MD|
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