Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy
This trial is active, not recruiting.
|Conditions||pain, breast cancer|
|Sponsor||Hospices Civils de Lyon|
|Start date||December 2004|
|Trial size||40 participants|
|Trial identifier||NCT00129597, 2004.349|
Prevalence of chronic pain after mastectomy is beyond 50% 3 months after surgery. This pain is related to a sensitization of the central nervous system through N-methyl-D-asparate (NMDA) receptors. Ketalar might prevent the occurrence of chronic pain by anti-NMDA properties after mastectomy.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
To evaluate the effect of perioperative ketalar on pain intensity 3 months after a mastectomy
Pain intensity is evaluated by an appropriate questionnaire 1 and 3 months after surgery.
To evaluate the incidence of chronic pain after mastectomy, the impact on life quality, and the area of hyperalgesia
Female participants from 18 years up to 80 years old.
Inclusion Criteria: - Mastectomy in patients 18 to 80 years old Exclusion Criteria: - American Society of Anesthesiology (ASA) class >= 3 - Renal, heart or hepatic failure - Allergy to ketalar - Psychiatric disease - Chronic antalgic treatment
|Official title||Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy|
|Principal investigator||Vincent PIRIOU, MD|
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