Overview

This trial is active, not recruiting.

Conditions asthma, healthy
Treatments allergen inhalation, withdrawal of medication, sputum induction
Sponsor Groningen Research Institute for Asthma and COPD
Start date July 2005
End date February 2007
Trial size 20 participants
Trial identifier NCT00116311, METc2004-253

Summary

The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased adenosine receptor expression versus control subjects.

We also want to study the effects of allergen inhalation on adenosine receptor expression in asthmatics. We believe that adenosine receptor expression will be upregulated after allergen inhalation.

Both hypotheses are being tested in sputum and peripheral blood.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model defined population
Primary purpose screening
Time perspective cross-sectional

Eligibility Criteria

Male or female participants from 18 years up to 50 years old.

Asthmatic Subjects - Inclusion Criteria: - Clinical diagnosis of asthma - Steroid naive or subjects not using their inhaled steroids for the last 4 weeks, short-acting beta-agonist for rescue medication - FEV1 > 70% of predicted - Positive skin prick test for house dust mite, cat or grass pollen - PC20 methacholine or histamine < 8 mg/ml Asthmatic Subjects - Exclusion Criteria: - Use of systemic steroids in the previous 6 weeks - Asthma exacerbations in the previous 6 weeks - Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago Healthy Subjects - Inclusion Criteria: - No airway complaints - FEV1 > 90% of predicted - Negative skin prick test - PC20 methacholine or histamine > 8 mg/ml Healthy Subjects - Exclusion Criteria: - Use of steroids in the previous 6 weeks - Current or ex-smokers with ≥ 10 pack-years (≥ 2 pipe pack-years), ex smokers who stopped less than 1 year ago

Additional Information

Official title Effects of Allergen Inhalation on Adenosine Receptor Expression and Mast Cell Activation in Peripheral Blood and Sputum of Asthmatics and Healthy Subjects
Principal investigator Dirkje S Postma, prof. MD PhD
Trial information was received from ClinicalTrials.gov and was last updated in March 2007.
Information provided to ClinicalTrials.gov by Groningen Research Institute for Asthma and COPD.