Overview

This trial is active, not recruiting.

Conditions recurrent thyroid cancer, stage iva follicular thyroid cancer, stage iva papillary thyroid cancer, stage ivb follicular thyroid cancer, stage ivb papillary thyroid cancer, stage ivc follicular thyroid cancer, stage ivc papillary thyroid cancer
Treatments decitabine, iodine i 131, recombinant thyrotropin alfa, fludeoxyglucose f 18, positron emission tomography
Phase phase 2
Sponsor National Cancer Institute (NCI)
Start date May 2004
End date January 2014
Trial size 40 participants
Trial identifier NCT00085293, 2003-0308, 5954, CDR0000368467, N01CM62207, NCI-2009-00033, P30CA016672

Summary

This phase II trial is studying how well decitabine works in treating patients with metastatic papillary thyroid cancer or follicular thyroid cancer that has stopped responding to radioactive iodine. Iodine I 131 (radioactive iodine) kills thyroid cancer cells. Metastatic thyroid cancer cells can lose the ability to be treated with radioactive iodine. Decitabine may help thyroid cancer cells regain the ability to respond to treatment with radioactive iodine.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
Patients receive decitabine IV over 1 hour on days 1-5 and 8-12 of weeks 1 and 2 (course 1). On week 3, patients undergo iodine I 131 (131I) scanning using thyrotropin alfa injections. Patients whose scan does not demonstrate iodine uptake continue suppressive thyroid hormone therapy but receive no further study therapy. These patients undergo study follow up. Patients whose scan demonstrates iodine uptake undergo thyroid hormone withdrawal on weeks 4-8 and receive a second course of decitabine (as in course 1) on weeks 7 and 8. Patients then receive 131I therapy on week 9.
decitabine 5-aza-dCyd
Given IV
iodine i 131 I 131
Undergo thyrotropin-alfa stimulated radioactive iodine scan
recombinant thyrotropin alfa Thyrogen
Undergo thyrotropin-alfa stimulated radioactive iodine scan
fludeoxyglucose f 18 18FDG
Optional correlative studies
positron emission tomography FDG-PET
Optional correlative studies

Primary Outcomes

Measure
Restoration of radioiodine uptake in metastatic lesions as demonstrated by diagnostic whole-body scanning after decitabine administration
time frame: Week 3

Secondary Outcomes

Measure
Efficacy of subsequent radioiodine therapy in terms of change in serum thyroglobulin level
time frame: 3 months
Efficacy of subsequent radioiodine therapy in terms of change in serum thyroglobulin level
time frame: 6 months
Efficacy of subsequent radioiodine therapy in terms of complete response (CR)/partial response (PR)/stable disease (SD) of any radiographic disease
time frame: 3 months
Efficacy of subsequent radioiodine therapy in terms of CR/PR/SD of any radiographic disease
time frame: 6 months
Change in fludeoxyglucose (FDG) uptake measured by positron emission tomography (PET) in metastatic tumor sites before and after DNA-methyltransferase inhibitor therapy (optional)
time frame: Baseline to 3 weeks
Frequency of adverse events according to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0
time frame: Up to 6 months

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Histologically confirmed papillary thyroid or follicular thyroid carcinoma: - Differentiated disease; - Metastatic disease documented by ultrasound, CT scan (without iodinated contrast), or MRI - All metastatic disease foci =< 10 mm in all dimensions - Must have been treated with total or near-total thyroidectomy AND at least 1 course of iodine I 131 (131I)(>=29.9 mCi) OR demonstrated negative uptake on a postoperative low-dose131I scan - Must have undergone whole body 131I scan 1-3 days after administration of =< 5.5 mCi of 131I demonstrating no visible iodine uptake within the lesions unless demonstrated negative uptake on a postoperative low-dose131I scan within the past 12 weeks: - Must have 24-hour urine iodine excretion =< 500 mcg within 1 week of 131I scan - Must be receiving thyroid hormone therapy AND have thyroid-stimulating hormone level =< 0.5 mU/L - No known brain metastases - Performance status: - ECOG 0-2 OR Karnofsky 60-100% - Hematopoietic: - Absolute neutrophil count >= 1,500/mm3; - Platelet count >= 100,000/mm3; - WBC >= 3,000/mm3 - Hepatic: - AST and ALT =< 2.5 times upper limit of normal; - Bilirubin normal - Renal: - Creatinine not elevated OR - Creatinine clearance >= 60 mL/min - Cardiovascular: - No symptomatic congestive heart failure; - No unstable angina pectoris; - No cardiac arrhythmia - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - No prior allergic reaction attributed to compounds of similar chemical or biological composition to decitabine - No concurrent uncontrolled illness - No active or ongoing infection - No psychiatric illness or social situation that would preclude study compliance - No prior cytotoxic chemotherapy for thyroid cancer - At least 6 months since prior external beam radiotherapy administered for locoregional disease in the thyroid bed or to the cervical or upper mediastinal lymph node regions (no more than 6,000 cGy) - More than 6 months since other prior radiotherapy and recovered - More than 6 months since prior therapeutic 131I > 10 mCi - More than 18 months since prior cumulative 131I activity of at least 500 mCi - More than 12 months since prior amiodarone (Unless 24-hour urinary iodine excretion is =< 500 mcg) - No concurrent combination antiretroviral therapy for HIV-positive patients - No other concurrent anticancer therapy - No other concurrent investigational agents - More than 6 months since prior intrathecal iodinated contrast (Unless 24-hour urinary iodine excretion is =< 500 mcg) - More than 3 months since prior IV or oral iodinated contrast for radiographic studies (Unless 24-hour urinary iodine excretion is =< 500 mcg)

Additional Information

Official title Phase II Study of Decitabine in Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Radioiodine
Principal investigator Steven Sherman
Description PRIMARY OBJECTIVE: I. Determine whether decitabine can restore iodine I 131 (131I) uptake in patients with metastatic papillary thyroid or follicular thyroid cancer lesions that are undetectable by low-dose iodine 131I scanning. SECONDARY OBJECTIVES: I. Determine the efficacy of 131I therapy, administered after restoration of 131I uptake by decitabine, in these patients. II. Determine the effect of decitabine on clinical and molecular markers of thyroid cancer cell differentiation in these patients. III. Determine the safety and tolerability of decitabine in patients undergoing thyroid hormone withdrawal-induced hypothyroidism and 131I therapy. OUTLINE: This is an open-label, multicenter study. Patients receive decitabine IV over 1 hour on days 1-5 and 8-12 of weeks 1 and 2 (course 1). On week 3, patients undergo iodine I 131 (131I) scanning using thyrotropin alfa injections. Patients whose scan does not demonstrate iodine uptake continue suppressive thyroid hormone therapy but receive no further study therapy. These patients undergo study follow up. Patients whose scan demonstrates iodine uptake undergo thyroid hormone withdrawal on weeks 4-8 and receive a second course of decitabine (as in course 1) on weeks 7 and 8. Patients then receive 131I therapy on week 9. Patients are followed at 3 and 6 months.
Trial information was received from ClinicalTrials.gov and was last updated in May 2014.
Information provided to ClinicalTrials.gov by National Cancer Institute (NCI).