This trial is active, not recruiting.

Conditions psychotic disorders, schizophrenia
Treatments medication adherence therapy, friendly support group
Sponsor Veterans Medical Research Foundation
Collaborator National Institute of Mental Health (NIMH)
Start date September 2002
End date May 2007
Trial size 240 participants
Trial identifier NCT00071604, DATR A4-GPS, R01 MH62849, R01MH062849


This study will determine whether Medication Adherence Therapy (MAT) can improve medication adherence and lower the risk of rehospitalization in older patients with psychosis.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking double-blind

Eligibility Criteria

Male or female participants at least 40 years old.

Inclusion Criteria: - DSM-IV criteria for schizophrenia or schizoaffective disorder - Outpatient status at the time of enrollment - Currently prescribed maintenance treatment with antipsychotic medication (typical or atypical, oral or depot)

Additional Information

Official title Medication Adherence in Older Psychotic People
Principal investigator Jonathan Lacro, PharmD
Description Psychoses are among the most common and serious psychiatric disorders. Currently, the most effective treatment for psychoses involves the use of antipsychotic or neuroleptic medications. Unfortunately, pharmacologic regimens often do not achieve their goals because of poor medication adherence. Nonadherence to antipsychotic treatment is a considerable public health problem that leads to myriad clinical and economic burdens, including psychotic relapse, increased clinic and emergency room visits, and rehospitalization. Participants in this study are randomly assigned to receive either MAT or supportive treatment for 12 weeks. MAT is given in 15 sessions and consists of motivational interviewing, education, and social skills and behavior modification. Individual MAT sessions are held in Weeks 1 and 12; small group sessions take place in Weeks 2 through 11. Three monthly booster group sessions begin in Week 16. Participants are assessed at baseline and at 3, 6, and 12 months. Medication adherence, psychopathology, quality of life, medication side effects, health beliefs, and functioning are assessed.
Trial information was received from ClinicalTrials.gov and was last updated in May 2013.
Information provided to ClinicalTrials.gov by Veterans Medical Research Foundation.