Overview

This trial is active, not recruiting.

Condition breast cancer
Treatments pegfilgrastim, ac regimen, cyclophosphamide, doxorubicin hydrochloride, paclitaxel
Phase phase 3
Sponsor Southwest Oncology Group
Collaborator National Cancer Institute (NCI)
Start date November 2003
End date February 2017
Trial size 3250 participants
Trial identifier NCT00070564, CDR0000334899, S0221, U10CA032102

Summary

RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them after surgery may kill any remaining tumor cells. It is not yet known which combination chemotherapy regimen is more effective in treating resected breast cancer.

PURPOSE: This randomized phase III trial is comparing 2 different regimens of combination chemotherapy to see how well they work in treating patients who have undergone surgery for stage I, stage II, or stage III breast cancer.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Intervention model factorial assignment
Masking open label
Primary purpose treatment
Arm
(Active Comparator)
(closed 11/10/10) Patients receive doxorubicin IV and cyclophosphamide IV on day 1 and pegfilgrastim subcutaneously (SC) on day 2 or filgrastim (G-CSF) SC on days 3-10. Treatment repeats every 14 days for 6 courses. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 3 hours on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 6 courses.
pegfilgrastim
Given IV
ac regimen
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
paclitaxel
Given IV
(Experimental)
(closed 11/10/10) Patients receive doxorubicin IV on day 1, oral cyclophosphamide on days 1-7, and G-CSF SC on days 2-7. Treatment repeats every 7 days for 15 courses. Beginning 2 weeks after completion of cyclophosphamide, patients receive paclitaxel and pegfilgrastim as in arm I.
pegfilgrastim
Given IV
ac regimen
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
paclitaxel
Given IV
(Active Comparator)
(closed 11/10/10) Patients receive doxorubicin, cyclophosphamide, and pegfilgrastim or G-CSF as in arm I. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 1 hour on day 1. Treatment repeats every 7 days for 12 courses.
pegfilgrastim
Given IV
ac regimen
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
paclitaxel
Given IV
(Experimental)
(closed 11/10/10) Patients receive doxorubicin, cyclophosphamide, and G-CSF as in arm II. Beginning 2 weeks after completion of cyclophosphamide, patients receive paclitaxel as in arm III.
pegfilgrastim
Given IV
ac regimen
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
paclitaxel
Given IV
(Experimental)
Patients receive doxorubicin IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 4 courses. Patients receive doxorubicin IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 6 courses. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 3 hours on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 6 courses.
pegfilgrastim
Given IV
ac regimen
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
paclitaxel
Given IV
(Experimental)
Patients receive doxorubicin, cyclophosphamide, and pegfilgrastim as in arm V. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 1 hour on day 1. Treatment repeats every 7 days for 12 courses.
pegfilgrastim
Given IV
ac regimen
Given IV
cyclophosphamide
Given IV
doxorubicin hydrochloride
Given IV
paclitaxel
Given IV

Primary Outcomes

Measure
Disease-free survival by medical history, physical exam, and mammograms every 6 months (annually for mammograms) for 5 years and then annually for 15 years or until death
time frame: every 6 months (annually for mammograms) for 5 years and then annually for 15 years or until death
Compare overall survival of patients among the 2 treatment arms by medical history and physical exam every 6 months for 5 years and then annually
time frame: Every 6 months for 5 years then annually
Compare toxicity among the 2 treatment arms by medical history and physical exam every 6 months for 5 years and then annually
time frame: Every 6 months for 5 years and then annually

Secondary Outcomes

Measure
Compare disease-free survival of patients among the 2 treatment arms by assessment of medical history, physical exam, and mammograms every 6 months (annually for mammograms) for 5 years and then annually for 15 years or until death
time frame: every 6 months (annually for mammograms) for 5 years and then annually for 15 years or until death
Compare prognostic biomarkers with outcome and the interaction of these markers with treatment as measured by gene expression analysis before study entry
time frame: pre-study

Eligibility Criteria

Male or female participants at least 18 years old.

DISEASE CHARACTERISTICS: - Histologically confirmed stage I-III invasive breast cancer - Operable disease - Stage I, II, IIIA, and IIIC (T1-3, N3a only) - No T4 tumors - High-risk disease, defined by 1 of the following: - Tumor ≥ 2 cm in greatest diameter (includes both invasive and intraductal component) - Patients with nodal status of N0+ (i.e., no cluster of tumor cells in any node greater than 0.2 mm) are considered to be node negative and must have a primary tumor ≥ 2 cm in size or have a tumor ≥ 1 cm with high risk features - Patients who are node negative on the basis of a sentinel node procedure and fewer than 6 axillary nodes are removed are eligible OR at least 6 axillary or intramammary nodes must be negative - Tumor ≥ 1 cm in diameter and meeting 1 of the following criteria: - ER-negative and PgR-negative - ER-positive or PgR-positive with a Genomic Health Recurrence Score of ≥ 26 - One or more axillary or intramammary nodes are involved by metastatic breast cancer - If one or more nodes is involved, a minimum of 6 axillary or intramammary nodes must have been examined histologically - Patients with N0(I+) disease will be considered node negative - HER2/neu-positive tumors (3+ by immunohistochemical staining or amplified by fluorescence in-situ hybridization) allowed - Bilateral synchronous breast cancer diagnosed within 1 month of each other allowed provided the higher TNM stage primary tumor meets the eligibility criteria - Prior modified radical mastectomy OR local excision of all tumors with axillary lymph node dissection or sentinel node resection required - No more than 84 days since prior surgery for the primary tumor and/or axilla - Final resection margins for the primary tumor must be histologically negative for invasive cancer and ductal carcinoma in situ - Resection margins positive for lobular carcinoma in situ are allowed - Hormone receptor status: - Estrogen receptor status known - Progesterone receptor status known PATIENT CHARACTERISTICS: Age - 18 and over Sex - Male or female Menopausal status - Not specified Performance status - Zubrod 0-2 Life expectancy - Not specified Hematopoietic - Absolute neutrophil count at least 1,200/mm^3 - Platelet count at least 100,000/mm^3 Hepatic - Bilirubin no greater than upper limit of normal (ULN) - Alkaline phosphatase no greater than 2 times ULN - SGOT or SGPT no greater than 2 times ULN Renal - Creatinine no greater than ULN Cardiovascular - No congestive heart failure - No active angina pectoris - LVEF greater than or equal to the lower limit of normal* by MUGA or echocardiogram NOTE: Patients age 60 and over OR with a history of hypertension Other - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, in situ cervical carcinoma, or lobular carcinoma in situ of the breast - Prior invasive breast cancer or ductal carcinoma in situ allowed if disease-free for 5 years - HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - No prior cytotoxic chemotherapy for this breast cancer - No prior chemotherapy with an anthracycline, anthracenedione, or taxane Endocrine therapy - Not specified Radiotherapy - No prior radiotherapy for this malignancy - At least 2 weeks since prior radiotherapy for ductal carcinoma in situ Surgery - See Disease Characteristics

Additional Information

Official title Phase III Trial of Continuous Schedule AC + G vs. Q 2 Week Schedule AC, Followed by Paclitaxel Given Either Every 2 Weeks or Weekly for 12 Weeks as Post-Operative Adjuvant Therapy in Node-Positive or High-Risk Node-Negative Breast Cancer
Description OBJECTIVES: - Compare the disease-free survival of patients with node-positive or high-risk node-negative breast cancer treated with 2 different schedules of adjuvant doxorubicin, cyclophosphamide, and paclitaxel. - Compare the overall survival of patients treated with these regimens. - Compare the toxic effects of these regimens in these patients. - Correlate outcome with putative prognostic markers in patients treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are randomized to 1 of 2 treatment arms (arms V and VI) (arms I-IV closed 11/10/10). - Arm I: (closed 11/10/10) Patients receive doxorubicin IV and cyclophosphamide IV on day 1 and pegfilgrastim subcutaneously (SC) on day 2 or filgrastim (G-CSF) SC on days 3-10. Treatment repeats every 14 days for 6 courses. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 3 hours on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 6 courses. - Arm II: (closed 11/10/10) Patients receive doxorubicin IV on day 1, oral cyclophosphamide on days 1-7, and G-CSF SC on days 2-7. Treatment repeats every 7 days for 15 courses. Beginning 2 weeks after completion of cyclophosphamide, patients receive paclitaxel and pegfilgrastim as in arm I. - Arm III: (closed 11/10/10) Patients receive doxorubicin, cyclophosphamide, and pegfilgrastim or G-CSF as in arm I. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 1 hour on day 1. Treatment repeats every 7 days for 12 courses. - Arm IV: (closed 11/10/10) Patients receive doxorubicin, cyclophosphamide, and G-CSF as in arm II. Beginning 2 weeks after completion of cyclophosphamide, patients receive paclitaxel as in arm III. - Arm V: Patients receive doxorubicin IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 4 courses. Patients receive doxorubicin IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 6 courses. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 3 hours on day 1 and pegfilgrastim SC on day 2. Treatment repeats every 14 days for 6 courses. - Arm VI: Patients receive doxorubicin, cyclophosphamide, and pegfilgrastim as in arm V. Beginning 2 weeks after completion of doxorubicin and cyclophosphamide, patients receive paclitaxel IV over 1 hour on day 1. Treatment repeats every 7 days for 12 courses. In all arms, treatment continues in the absence of disease progression or unacceptable toxicity. In all arms patients with HER2/neu-positive tumors also receive trastuzumab (Herceptin®) weekly or every 3 weeks beginning concurrently with paclitaxel OR 3 months after the last dose of paclitaxel and continuing for up to 52 weeks. In all arms, patients with estrogen-receptor or progesterone-receptor positive tumors receive hormonal therapy beginning within 28 days of the completion of adjuvant chemotherapy or radiotherapy (if given). After finishing study treatment patients are followed up every 6 months for 5 years and then once a year for up to 15 years. PROJECTED ACCRUAL: A total of 3,250 patients will be accrued for this study.
Trial information was received from ClinicalTrials.gov and was last updated in September 2015.
Information provided to ClinicalTrials.gov by Southwest Oncology Group.