This trial is active, not recruiting.

Condition brain and central nervous system tumors
Treatments cisplatin, lomustine, vincristine sulfate, adjuvant therapy, radiation therapy
Phase phase 3
Sponsor University of Leicester
Start date February 2003
Trial size 316 participants
Trial identifier NCT00053872, CDR0000269521, EU-20244, SIOP-PNET-4, UKCCSG-CNS-2003-05


RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving radiation therapy in different ways with combination chemotherapy may kill any remaining tumor cells following surgery. It is not yet known which radiation therapy regimen combined with combination chemotherapy is more effective in treating medulloblastoma.

PURPOSE: Randomized phase III trial to compare different radiation therapy regimens plus combination chemotherapy in treating children who have undergone surgery for medulloblastoma.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Primary purpose treatment

Primary Outcomes

Comparison of event-free survival at 3 years
time frame:

Secondary Outcomes

Comparison of overall survival
time frame:
Comparison of the pattern of relapse (i.e., local relapse [tumor bed and posterior fossa outside tumor bed])
time frame:
Comparison of late sequelae, in terms of health status, quality of life, hearing loss, and endocrine deficiencies
time frame:
Toxicity of neurosurgery
time frame:

Eligibility Criteria

Male or female participants from 3 years up to 21 years old.

DISEASE CHARACTERISTICS: - Histologically confirmed medulloblastoma, including the following variants: - Classic - Nodular/desmoplastic - Large cell - Melanotic - Medullomyoblastoma - Prior total or subtotal surgical removal of tumor within the past 28-40 days - No more than 1.5 cm^2 residual tumor by early postoperative MRI or CT scan - No brainstem or supratentorial primitive neuroectodermal tumor - No atypical teratoid rhabdoid tumor - No known predisposition to medulloblastoma (e.g., Gorlin's syndrome) - No CNS metastasis (supratentorial, arachnoid of the posterior fossa, or craniospinal axis) by MRI - No clinical evidence of metastasis outside the CNS - No tumor cells in lumbar cerebrospinal fluid by cytospin PATIENT CHARACTERISTICS: Age - 3 to 21 Performance status - Not specified Life expectancy - Not specified Hematopoietic - Hematological function less than CTC grade 2 Hepatic - Liver function less than CTC grade 2 Renal - Renal function less than CTC grade 2 Other - Not pregnant - Fertile patients must use effective contraception - Able to receive radiotherapy twice daily - Vital functions within age-appropriate normal range - Audiological function less than CTC grade 2 - No medical contraindication to radiotherapy or chemotherapy PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Concurrent dexamethasone as an antiemetic allowed, provided all other therapies have failed Radiotherapy - No concurrent cobalt irradiation Surgery - See Disease Characteristics Other - No prior treatment for brain tumor or any other malignancy

Additional Information

Official title A Prospective Randomised Controlled Trial Of Hyperfractionated Versus Conventionally Fractionated Radiotherapy In Standard Risk Medulloblastoma
Description OBJECTIVES: - Compare the event-free survival rate in pediatric patients with standard-risk medulloblastoma treated with conventional vs hyperfractionated radiotherapy and vincristine followed by maintenance with cisplatin, lomustine, and vincristine. - Compare the overall survival of patients treated with these regimens. - Compare the pattern of relapse, especially local relapse (tumor bed or posterior fossa outside tumor bed), in patients treated with these regimens. - Determine the toxicity of surgery and whether there are identifiable factors that correlate with toxicity in these patients. - Determine the impact of any surgical complications on commencement of adjuvant therapy and event-free survival of these patients. - Compare late sequelae, in terms of health status, endocrine deficiencies, and hearing loss, in patients treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to country. Patients are randomized to 1 of 2 treatment arms. - Arm I: Within 28-40 days after surgical resection, patients undergo conventional fractionated radiotherapy once daily, 5 days a week, for 6-7 weeks. Patients also receive vincristine IV once weekly for 8 weeks. - Arm II: Beginning as in arm I, patients undergo hyperfractionated radiotherapy twice daily, 5 days a week, for 6-7 weeks. Patients also receive vincristine as in arm I. - Maintenance chemotherapy:Six weeks after completion of radiotherapy, all patients receive cisplatin IV over 6 hours and oral lomustine on day 1 and vincristine IV on days 1, 8, and 15. Treatment repeats every 6 weeks for 8 courses. Patients are followed at least every 6 months for 3 years. Peer Reviewed and Funded or Endorsed by Cancer Research UK PROJECTED ACCRUAL: A total of 316 patients (158 per treatment arm) will be accrued for this study within 4 years.
Trial information was received from ClinicalTrials.gov and was last updated in June 2014.
Information provided to ClinicalTrials.gov by National Cancer Institute (NCI).