This trial is active, not recruiting.

Condition hiv infections
Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Trial size 1100 participants
Trial identifier NCT00046280, MACS


This is a comprehensive observational study of HIV infection in homosexual and bisexual men.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Time perspective prospective

Eligibility Criteria

Male participants at least 18 years old.

Inclusion Criteria: - HIV negative, or - HIV positive and no history or current use of highly active antiretroviral therapy (HAART), or - HIV positive HAART recipient with documentation of HAART initiation, no AIDS diagnosis prior to HAART initiation, and a CD4 cell count and HIV-1 RNA measurement within 6 months prior to first HAART use. - Sexual intercourse with men or at least 5 male or female partners in the 5 years prior to enrollment. Exclusion Criteria: - Injection drug use within 1 year of enrollment. - Perinatally acquired HIV infection.

Additional Information

Description The Multicenter AIDS Cohort Study (MACS) provides important information about the changing nature of HIV-mediated disease progression, the impact of antiretroviral treatment, the nature of HIV pathogenesis, and viral and host genetic factors. This study will also assess the long-term patterns of therapy use and risk-taking behaviors. Patients will have study visits every 6 months. The visits will include interviews, specimen collection, and a physical examination.
Trial information was received from ClinicalTrials.gov and was last updated in November 2012.
Information provided to ClinicalTrials.gov by National Institute of Allergy and Infectious Diseases (NIAID).