Overview

This trial is active, not recruiting.

Conditions osteoporosis, liver transplantation
Sponsor National Center for Research Resources (NCRR)
Trial size 40 participants
Trial identifier NCT00008788, NCRR-M01RR00400-0664

Summary

This pilot project aims to 1) estimate the prevalence of osteoporosis in adults having undergone liver transplantation in childhood, and 2) identify risk factors for osteoporosis in this group. We aim to study 40 individuals.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model defined population
Time perspective cross-sectional

Eligibility Criteria

Male or female participants from 16 years up to 40 years old.

- Liver transplantation in childhood or young adulthood

Additional Information

Official title Osteoporosis in Children and Adults Following Liver Transplantation
Description Background: Osteoporosis is defined as an absolute decrease in the amount of bone (volume and/or density). Chronic liver disease is associated with osteoporosis in both adults and children. Bone density is also decreased in the months immediately after liver transplantation, but improves to pretransplant values after 1 to 2 years. Immunosuppressive agents, most notably steroids, are a cause of osteoporosis. However, studies on adults have shown that bone densities afer transplantation continue to improve within the normal range for healthy adults. In the case of children, bone accretion is necessary for growth. Chronic liver disease and transplantation in childhood will have an adverse effect on bone metabolism and the outcome in terms of bone density after the growth period cannot be predicted on individuals transplanted as adults or other transplant groups.
Trial information was received from ClinicalTrials.gov and was last updated in June 2005.
Information provided to ClinicalTrials.gov by National Center for Research Resources (NCRR).