Determinants of Disease Severity in Amyotrophic Lateral Sclerosis
This trial is active, not recruiting.
|Condition||amyotrophic lateral sclerosis|
|Sponsor||National Institute of Neurological Disorders and Stroke (NINDS)|
|Collaborator||Massachusetts General Hospital|
|Start date||March 1998|
|Trial size||75 participants|
|Trial identifier||NCT00004457, 199/13650, MGH-1K08NS01896, MGH-97-7231|
I. Determine specific clinical features, molecular abnormalities, and laboratory-based biological markers of free radical stress that are associated with amyotrophic lateral sclerosis and influence disease severity.
|Observational model||defined population|
Male or female participants at least 18 years old.
PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Clinically diagnosed probable or definite, sporadic or familial amyotrophic lateral sclerosis --Patient Characteristics-- Pulmonary: No artificial ventilation required Other: No other neurodegenerative diseases No concurrent or history of unstable medical illness
|Description||PROTOCOL OUTLINE: This is a screening and diagnostic study. Blood and urine samples are collected from patients every 2 months for 1 year. All samples are evaluated for measures of free radical damage and levels of the body's own antioxidant activity.|
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