Overview

This trial is active, not recruiting.

Conditions ovarian cancer, primary peritoneal cavity cancer
Treatment yttrium y 90 monoclonal antibody hmfg1
Phase phase 3
Sponsor Jonsson Comprehensive Cancer Center
Collaborator National Cancer Institute (NCI)
Start date December 1998
Trial identifier NCT00004115, ANTISOMA-SMART22, CDR0000067341, NCI-G99-1604, UCLA-9712040

Summary

RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known whether monoclonal antibody therapy is more effective than observation for ovarian cancer or primary peritoneal cancer that is in remission.

PURPOSE: Randomized phase III trial to compare the effectiveness of monoclonal antibody therapy with that of observation in treating patients who have ovarian cancer or primary peritoneal cancer in remission following surgery and chemotherapy.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Primary purpose treatment

Eligibility Criteria

Female participants at least 18 years old.

DISEASE CHARACTERISTICS: - Histologically proven stage IC, II, III, or IV ovarian epithelial carcinoma or primary peritoneal serous carcinoma - Prior complete response to 1 platinum-based chemotherapy regimen consisting of at least 5 courses - Absence of disease on physical and radiological exam (CT scan/MRI) - CA 125 normal - No visible evidence of malignant disease on second-look laparoscopy - No disease relapse even if complete response to a second course of chemotherapy - Prior bilateral oophorectomy with or without salpingectomy, omentectomy, and total or partial abdominal hysterectomy required - No known metastases PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - ECOG 0-2 Life expectancy: - At least 3 months Hematopoietic: - WBC at least 3,000/mm^3 - Platelet count at least 100,000/mm^3 - Hemoglobin at least 10.0 g/dL Hepatic: - SGOT/SGPT no greater than 2 times upper limit of normal Renal: - Creatinine no greater than 2.0 mg/dL Other: - No other malignancy except basal cell skin cancer - No serious physical or psychiatric disease that would preclude study entry - No significant loculation that would preclude good distribution of study medication - Human antimouse antibody negative PRIOR CONCURRENT THERAPY: Biologic therapy: - No prior murine antibody Chemotherapy: - See Disease Characteristics - No more than 4-8 weeks since prior chemotherapy Endocrine therapy: - Not specified Radiotherapy: - Not specified Surgery: - See Disease Characteristics Other: - No concurrent participation in other trials involving adjuvant cancer treatment - No other concurrent experimental therapies

Additional Information

Official title Multicenter Randomized Survival Study of Monoclonal Antibody Radioimmunotherapy: A Multinational Study in Patients With Ovarian Carcinoma Using the HMFG1 Antibody Labeled With 90Yttrium
Description OBJECTIVES: - Determine the efficacy of yttrium Y 90 monoclonal antibody HMFG1, in terms of survival, in patients with ovarian epithelial carcinoma in remission after debulking surgery and platinum-based chemotherapy. - Determine the toxicity and tolerability of this treatment regimen in these patients. - Determine the quality of life of patients treated with this regimen. - Evaluate this treatment regimen, in terms of the time to relapse, ECOG performance status, frequency of hospitalization, changes in concurrent medication, and incidence and severity of adverse events, in this patient population. OUTLINE: This is a randomized, parallel, multicenter study. Patients are randomized to one of two treatment arms. - Arm I: Patients receive standard therapy (observation). - Arm II: After imaging studies of the peritoneal cavity to verify adequate fluid distribution, patients receive yttrium Y 90 monoclonal antibody HMFG1 intraperitoneally over 1 minute. Quality of life is assessed in all patients prior to randomization, at weeks 4 and 8, at 3 months, and then every 3 months thereafter. Patients in arm I are followed at weeks 1, 4, and 8. Patients in arm II are followed weekly for 6 weeks and at weeks 8 and 12. All patients are followed every 3 months for 3 years. PROJECTED ACCRUAL: A total of 420 patients (210 per treatment arm) will be accrued for this study.
Trial information was received from ClinicalTrials.gov and was last updated in September 2013.
Information provided to ClinicalTrials.gov by National Cancer Institute (NCI).